Palomid 529
CAS No. 914913-88-5
Palomid 529 ( Palomid 529; Palomid-529; Palomid529 )
产品货号. M17658 CAS No. 914913-88-5
Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥551 | 有现货 |
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25MG | ¥1077 | 有现货 |
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50MG | ¥2001 | 有现货 |
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100MG | ¥3313 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Palomid 529
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
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产品描述Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells.
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同义词Palomid 529; Palomid-529; Palomid529
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通路Others
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靶点Other Targets
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受体mTORC1; mTORC2
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研究领域Cancer
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适应症——
化学信息
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CAS Number914913-88-5
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分子量406.43
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分子式C24H22O6
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纯度98%
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溶解度DMSO : 20.5 mg/mL. 50.44 mM;
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SMILESCOc1ccc(COc2c(OC)cc3c(oc(=O)c4c3ccc(c4)C(C)O)c2)cc1
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化学全称8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xue Q, et al. Y Res, 2008, 68(22), 9551-9557.
产品手册
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